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Umbilical vessels have thick muscular walls with a muscular sphincter The glycogen levels decrease in the late fetal life and reach adult levels by term In early fetal life, the high cardiac glycogen levels that prevail may protect the heart from acute periods of hypoxia The fetal oxyhemoglobin dissociation curve is shifted to the left at equal pressure of O2, fetal blood carries significantly more O2 than does maternal O2 saturation of maternal blood in placenta is so low that the fetus might suffer hypoxic damage if fetal red cells did not have a greater O2 affinity than adultįetal red cells contain fetal Hb (Hb F) while adult red cells contain adult Hb (Hb A) Tissues of fetal and newborn mammals have a remark-able but poorly understood resistance to hypoxia O2 saturation of the blood in lower aorta and UA is 60 % saturated with O2 The head of fetus receives the better-oxygenated blood from the LVįrom aorta, some of blood is pumped into the umbilical arteries (UA) and back to placenta Relatively unsaturated blood from RV is diverted into trunk and lower body Most of the blood from PA passes into aorta via ductus arteriosus Resistance of collapsed lungs is very high Most of blood from SVC enters right ventricle (RV) and is expelled into pulmonary artery (PA) Most of the blood entering heart through IVC is diverted directly to left atrium (LA) via foramen ovale left ventricle (LV) Portal and systemic venous blood is only 26 % saturated with O2 Is also the route by which all nutritive materialsĮnter the fetus and wastes are discharged toīlood in umbilical vein (UV) 80 % saturated with O2 (in arterial circulation of adult: 98 % )ĭuctus venosus (DV) diverts some of the blood directly to Inferior Vena Cava (IVC) and remainders mixes with portal blood However cellular layers covering the villi are thicker and less permeable than the alveolar membranes in the lungs and exchange is much less efficient O2 and nutrients are derived from maternal bloodĬO2 and wastes are eliminated into maternal blood
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Lungs, kidneys, and gastrointestinal tract are nonfunctional
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